Vintage-like doctor's bag made of full grain leather is a great choice for everyday carry! Looks great with any outfit. This leather doctor's backpack is made of full-grain leather. The strongest and most durable part of the hide of an animal is just below the hair. Full-grain leather is the strongest and most durable leather. Additionally, since the grain is so tight, it resists moisture very well. Over time, full-grain leather will look nicer and nicer and develop a patina from being handled. However, even the highest quality leather will have small irregularities